A phase 2 trial of personalized cytotoxic therapy based on tumor immunohistochemistry in previously treated metastatic pancreatic cancer patients

Figure 2 Overall survival. Time on study ranged from 0–8.6 months (median 1.3 months, 95% CI, 1–1.6 months). All patients have died, with survival ranging from 0.4 months to 26.8 months. The median PFS is 2.4 months (95% CI, 2.1–3.9 months) and median survival is 5.7 months (95% CI, 3.8–8.2 months). The 1-year survival rate was 20% (95% CI, 7–33%) for all 35 patients.

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Preoperative accuracy of gastric cancer staging in patient selection for preoperative therapy: race may affect accuracy of endoscopic ultrasonography

Table 3 Multivariate analysis of factors predicting T-staging accuracy of endoscopic ultrasonography 

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Stereotactic body radiotherapy for locally-advanced unresectable pancreatic cancer—patterns of care and overall survival

Figure 1 Utilization of SBRT and CFRT from 1998 to 2012 for individuals with locally-advanced pancreatic cancer. SBRT, stereotactic body radiotherapy; CFRT, conventionally fractionated radiotherapy.

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Adjuvant chemotherapy and outcomes in esophageal carcinoma

Figure 2 Overall Survival and recurrence free survival comparisons for the propensity score matched cohort. (A) OS comparison for the propensity score matched cohort. The median OS was 2.7 years (CI, 1.6–3.7) in the group that received adjuvant chemotherapy and 2.8 years (CI, 2.0–3.6) in the group that did not receive any postoperative therapy (P=0.421)...

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The International Duration Evaluation of Adjuvant Chemotherapy study: implications for clinical practice

Table 1 Randomized phase III trials that constitute the IDEA project

After long anticipation, the preliminary results of the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) study were reported at the American Society of Clinical Oncology on June 4, 2017.

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The role of neoadjuvant radiotherapy for locally-advanced rectal cancer with resectable synchronous metastasis

Figure 3: Overall survival: 5-year overall survival rates were: 43.3% (95% CI: 30.1, 62.3%) (no RT) vs. 58.3% (95% CI: 43.4%, 78.2%) (RT). The 5-year disease-specific survival rates were 49.6% (95% CI: 35.5%, 69.4%) (no RT) vs. 60.5% (95% CI: 45.0%, 81.33%) (RT). RT, radiotherapy.

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A margin distance analysis of the impact of adjuvant chemoradiation on survival after pancreatoduodenectomy for pancreatic adenocarcinoma

Figure 1: Kaplan-Meier estimates for (A) recurrence-free survival (RFS) and (B) overall survival (OS) for patients stratified by margin clearance (MC) following pancreaticoduodenectomy (PD)

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Novel Biologics In Era of Precision Medicine by Drs. Andrea Wang-Gillam and Kian-Huat Lim

This issue is organized into four sections: (I) Evolution In Cancer Treatment: Adding Genomics to Histology; (II) Biologics in Various GI Malignancies; (III) Challenges in Biologics; (IV) Ongoing Perspectives and Clinical Trials.  It is dedicated to providing readers with an updated and concise overview of novel biologics that are being developed or tested in various GI cancer types. Efforts toward the molecular classification for each GI cancer type will be discussed, and expert insight into the challenges of precision oncology including treatment resistance, side effects and cost-effectiveness will be presented.  

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Neoadjuvant transarterial radiation lobectomy for colorectal hepatic metastases: a small cohort analysis on safety, efficacy, and radiopathologic correlation

Contrast-enhanced CT of the abdomen in the portal venous phase demonstrating a large heterogeneously enhancing mass in the right hepatic lobe (arrow in A) in patient 1 prior to radiation lobectomy. Two months following RL, the lesion is smaller and necrotic without evidence of internal enhancement (arrow in B). Note FLR hypertrophy (star) and decreased volume of the right hepatic lobe (arrowhead).

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Optimizing the management of hepatobiliary neoplasms: a multidisciplinary and molecular challenge by Dr. Jimmy Hwang

In this issue of Journal of Gastrointestinal Oncology (JGO), a variety of comprehensive reviews highlight the multidisciplinary advancements and efforts required for optimizing care for patients with hepatobiliary neoplasms. This series, written by experts from a variety of oncologic specialties, highlights the imperative of coordinated multidisciplinary efforts both in the clinic and, most importantly, in future research endeavors that incorporate the growing body of molecular, technical, and pharmacologic advances.

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