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Interviews with Outstanding Authors (2022)

In 2022, many JGO authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

JGO Annual Report (2021)

Greetings from the editorial office of Journal of Gastrointestinal Oncology (JGO).

We are glad to present the 2021 Annual Report of JGO, which has shown the number, internationality, monthly retrieval of JGO in PubMed and pageviews of JGO articles. The newly released 2021 Impact Factor of JGO is 2.892.

We would like to extend our sincere gratitude to our editorial board members, guest editors, reviewers, authors and readers. We wish you a happy, healthy and prosperous 2022 and we look forward to working with you to continue the success of JGO.

New Impact Factor for Journal of Gastrointestinal Oncology: 2.587

We are pleased to announce that the Journal of Gastrointestinal Oncology (JGO) has attained its latest impact factor update for the 2021 citation year: 2.587.

We will strive to follow the best practices in publishing. Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their valuable contributions.

Journal of Gastrointestinal Oncology (JGO) is now a member of Committee on Publication Ethics (COPE)

Starting from July 2021, AME Publishing Company is formally recognized a publisher member of Committee on Publication Ethics (COPE) and over 60 AME-published journals become a member of Committee on Publication Ethics (COPE), as part of AME’s commitment to best practice in scholarly publishing. Journal of Gastrointestinal Oncology (JGO) is among the list of COPE membership.

Current Management of Upper Gastrointestinal Malignancies (Ongoing)

The series on “Current Management of Upper Gastrointestinal Malignancies” is edited by Dr. Francisco Schlottmann, MD, MPH from Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA and Dr. Marco G. Patti, MD from Department of Surgery, University of Virginia, Charlottesville, VA, USA.

Surgery for Locally Advanced Pancreatic Cancer

In the time of rapidly emerging data on the feasibility of surgery in locally advanced pancreatic cancer (LAPC), this specialized edition of Journal of Gastrointestinal Oncology seeks to summarize and critically evaluate the existing data on the topic and to provide a guidance for best clinical practice for surgical resection and oncologic treatment of LAPC.

Reviewer of the Month (2020-21)

Over the years, many JGO reviewers have made outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Global GI Malignancies

The increasing issues of globalization and caring for our populations have created a unified effort of all healthcare stakeholders worldwide. Population health has emerged to integrate public health, health policy, quality and safety, as well as chronic care management under one roof. Although the concept of population health has been around for generations, a measurable definition of “population-level health outcomes” with the health factors and policy/interventions that influence it was not reported until Kindig and Stoddart in 2003. This focus series of global GI malignancies from a population health management perspective is intended to provide a broad overview of relevant topics.

Current Strategies in Colon Cancer Management

Colorectal cancer is the second most common cancer in females and the third most common in males worldwide. In this issue of Journal of Gastrointestinal Oncology, we will focus on the surgical management of colon cancer and give an update on its latest developments.

Pancreatic Neuroendocrine Tumors

The incidence of pancreatic neuroendocrine tumors (pNETs) continues to increase, prompting renewed interest in the pathophysiology and treatment of this disease. This focused series comprehensively reviews the pathophysiology, tumorigenesis, available clinical trials, and approved therapies for patients with pNETs. A deeper understanding of these factors is necessary to enhance our efforts to improve patient improve patient outcomes through the application of more innovative treatment sequencing.

Implementation of transparent peer review at Journal of Gastrointestinal Oncology (JGO)

Editorial office, Journal of Gastrointestinal Oncology

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a transparent peer review process as an option for all manuscripts submitted to JGO from June 11, 2020.

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Vol 13, No 4 (August, 2022)

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Original Article

The efficacy and safety of gemcitabine-based combination therapy vs. gemcitabine alone for the treatment of advanced pancreatic cancer: a systematic review and meta-analysis

Zhaohuan Zhang, Shuling He, Ping Wang, Yibing Zhou

PDF Pages: 1967-1980 Full Text (315) Reporting Checklist COI Form Open Access

Whole-process nursing management for laparo-gastroscopic esophagectomy

Zhe Wang, Minxuan Wu, Hui Zhao, Lina Cao, Yufeng Ou, Ping Wang, Lingli Yang, Li Dong, Yiqun Zhang, Yaxing Shen

PDF Pages: 1516-1524 Full Text (364) Reporting Checklist Data Sharing Statement COI Form Open Access

Systematic review and meta-analysis of endoscopic ultrasonography in staging diagnosis of esophageal cancer after neoadjuvant radiotherapy and chemotherapy

Xiaodong Li, Yixiao Wang, Min Kong, Jiang Lin

PDF Pages: 1525-1540 Full Text (274) Reporting Checklist COI Form Open Access

MiR-107 inhibits the malignant biological behavior of esophageal squamous cell carcinoma by targeting TPM3

Peipei Zhang, Weiguang Zhang, Junfei Jiang, Zhimin Shen, Sui Chen, Shaobin Yu, Mingqiang Kang

PDF Pages: 1541-1555 Full Text (345) Reporting Checklist Data Sharing Statement COI Form Open Access

The prognostic value of an immune-related gene signature and infiltrating tumor immune cells based on bioinformatics analysis in primary esophageal cancer

Hailei Du, Shuai Pang, Yong Li, Lianggang Zhu, Junbiao Hang, Ling Chen

PDF Pages: 1556-1570 Full Text (528) Reporting Checklist COI Form Open Access

Interleukin 13 participates in terminal differentiation of esophageal squamous cell carcinoma cells

Jian Li, Wenjian Wang, Ke Wang, Guangwei Ma, Jing Shao, Weizhen Fang, Yiting Zhou, Jiatong Lin, Yabin Guo, Xinyuan Guan, Chaohui Duan

PDF Pages: 1571-1578 Full Text (289) Reporting Checklist Data Sharing Statement COI Form Open Access

Modified McKeown vs. traditional McKeown minimally invasive esophagectomy in improving short-term efficacy and the quality of life of esophageal cancers: a retrospective comparative cohort study

Ying Chen, Yujie Xie, Hai Zhang, Zuwei Li, Bomeng Wu, Cui Li, Wanli Lin

PDF Pages: 1579-1588 Full Text (288) Reporting Checklist Data Sharing Statement COI Form Open Access

Bioinformatics analysis of the prognostic and immunotherapeutic significance of NPRL2 in stomach adenocarcinoma

Yilin Pi, Yuning Zhan, Jitao Song, Xin Jin, Jing Chen

PDF Pages: 1589-1604 Full Text (519) Reporting Checklist COI Form Open Access

Lymph node metastases rate of locoregional and non-locoregional lymph node stations in gastric cancer

Mees Hendrik Siert de Jong, Suzanne Sarah Gisbertz, Mark Ivo van Berge Henegouwen, Werner Adriaan Draaisma

PDF Pages: 1605-1615 Full Text (320) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Analysis of safety and efficacy of laparoscopic radical gastrectomy combined with or without indocyanine green tracer fluorescence technique in treatment of gastric cancer: a retrospective cohort study

Xiaoning Chen, Zhengwei Zhang, Feng Zhang, Xuanchen Tao, Xu Zhang, Zeyu Sun, Shibo Sun

PDF Pages: 1616-1625 Full Text (325) Reporting Checklist Data Sharing Statement COI Form Open Access

Circ_0007099 upregulates GNG7 to function as a tumor inhibitor in gastric carcinoma by interacting with miR-425-3p

Zhipeng Zhang, Yikai Zhou, Na Zhou, Junda Yin, Xuechun Kuang

PDF Pages: 1626-1639 Full Text (449) Reporting Checklist Data Sharing Statement COI Form Open Access

Construction and validation of a novel prognostic model using the cellular senescence-associated long non-coding RNA in gastric cancer: a biological analysis

Guoqing Wang, Zhilei Mao, Xiao Zhou, Yiming Zou, Min Zhao

PDF Pages: 1640-1655 Full Text (337) Reporting Checklist COI Form Open Access

Identification of 8-gene risk prediction signature associated with NOTCH1 in stomach adenocarcinoma based on bioinformatics analysis

Dun Pan, Chun Lin, Xin Lin, Liangqing Li

PDF Pages: 1656-1667 Full Text (333) Reporting Checklist COI Form Open Access

Intratumoral CD8⁺ T cells as a potential positive predictor of chemoimmunotherapy response in PD-L1-negative advanced gastric cancer patients: a retrospective cohort study

Gangling Tong, Meiqin Zhu, Yaoxu Chen, Shubo Wang, Boran Cheng, Shubin Wang, Wangjun Liao

PDF Pages: 1668-1678 Full Text (433) Reporting Checklist Data Sharing Statement COI Form Open Access

Safety and effectiveness of apatinib in elderly patients with metastatic gastric cancer: a sub-analysis from the large-scale, prospective observational study of apatinib for gastric cancer treatment in a real-world clinical setting (AHEAD-G202)

Xiang Wang, Diansheng Zhong, Junping Zhang, Nan Du, Yuchuan Ren, Jinghua Gao, Likun Liu, Junyan Yu, Xiaomei Li, Liwen Ma, Aimin Zang, Mudan Yang, Yan Zhang, Jun Guo, Zheng Liu, Zhanzhao Fu, Junmei Jia, Jianfeng Diao, Zaiwen Fan, Xiang Song, Guozhong Li, Huaqing Wang, Chunmei Bai, Mei Guan, Xiubao Ren, Ruixing Zhang

PDF Pages: 1679-1689 Full Text (326) Reporting Checklist Data Sharing Statement COI Form Open Access

Identification of candidate biomarkers associated with gastric cancer prognosis based on an integrated bioinformatics analysis

Yong Liu, Da-Xiu Wang, Xiao-Jing Wan, Xian-Hong Meng

PDF Pages: 1690-1700 Full Text (370) Reporting Checklist COI Form Open Access

A post-marketing safety study of ramucirumab with FOLFIRI in patients with metastatic colorectal cancer

Toshiki Masuishi, Soshi Nagaoka, Long Jin, Kenichi Yoshizawa

PDF Pages: 1701-1710 Full Text (468) Reporting Checklist Data Sharing Statement COI Form Open Access

Validation of a genotype-based algorithm that identifies individuals with low, intermediate, and high serum CA19-9 levels in cancer-free individuals and in patients with colorectal cancer

Andreas Wannhoff, Simone Werner, Sha Tao, Hermann Brenner, Daniel N. Gotthardt

PDF Pages: 1711-1721 Full Text (301) Reporting Checklist Data Sharing Statement COI Form Open Access

Luteolin suppresses the growth of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway

Jingwen Jiang, Fengting Zhu, Hui Zhang, Tao Sun, Fangfang Fu, Xuewu Chen, Yanhong Zhang

PDF Pages: 1722-1732 Full Text (348) Reporting Checklist Data Sharing Statement COI Form Open Access

Surgical treatment and survival analysis of primary duodenal malignant tumor: a retrospective cohort study

Zhicheng Zhao, Jiehong Zhang, Chuan Li, Tong Liu, Weidong Li

PDF Pages: 1733-1745 Full Text (277) Reporting Checklist Data Sharing Statement COI Form Open Access

Lymphadenectomy with venation is preferred compared to skeletonization for patients with rectal and sigmoid colon cancer: a retrospective cohort study

Wei Ge, Hai-Yan Gong, Li-Hua Shao, Gang Chen, Yu-Dong Qiu

PDF Pages: 1746-1752 Full Text (222) Reporting Checklist Data Sharing Statement COI Form Open Access

High levels of triglycerides, apolipoprotein B, and the number of colorectal polyps are risk factors for colorectal polyp recurrence after endoscopic resection: a retrospective study

Jia-Yu Du, Gui-Ying Huang, Yong-Chun Xie, Nan-Xi Li, Zhi-Wei Lin, Li Zhang

PDF Pages: 1753-1760 Full Text (279) Reporting Checklist Data Sharing Statement COI Form Open Access

Low CPEB1 levels may predict the benefit of 5-fluorouracil treatment in patients with colon or stomach adenocarcinoma

Jing-Zhu Cao, Dan-Dan Niu, Zhi-Ping Huang, Yong-Gang Hong, Zhen-Guang Wang, Le Yang, Bo-Lun Zhao, Guang-Lei Qiao, Liu Ouyang

PDF Pages: 1761-1771 Full Text (392) Reporting Checklist Data Sharing Statement COI Form Open Access

The prognostic role of neutrophil-to-lymphocyte ratio and C-reactive protein in metastatic colorectal cancer using regorafenib: a systematic review and meta-analysis

Nan Zhao, Huilin Xu, Dingjie Zhou, Ximing Xu, Wei Ge, Dedong Cao

PDF Pages: 1772-1781 Full Text (351) Reporting Checklist COI Form Open Access

Diagnostic and prognostic potential of the novel biomarker nuclear cap binding protein subunit 2 (NCBP2) in colon adenocarcinoma

He Bu, Ting Cao, Xuesong Li, Yuekun Guo, Jiajia Guo, Yuxin Wang, Yunlong Sun, Donghong Wang

PDF Pages: 1782-1792 Full Text (342) Reporting Checklist Data Sharing Statement COI Form Open Access

Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis

Yuhan Tan, Kai Wang, Ying Kong

PDF Pages: 1793-1804 Full Text (324) Reporting Checklist Data Sharing Statement COI Form Open Access

Association of sleep duration, sleep apnea, and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis

Gang Wang, Jian-Jiang Wang, Chao-Huang Lin, Qing Zhou, Wei-Long Wang, Tao Qin, Xin Li, Ze-Jun Wang

PDF Pages: 1805-1817 Full Text (275) Reporting Checklist COI Form Open Access

Transcecum catheterization ileostomy is safe and effective to prevent anastomotic leakage in post-laparoscopic rectal cancer surgery: a single-center retrospective study

Hao Sun, Yongpeng He, Xiaohua Li, Zhixiong Chen, Maocai Tang, Jingkun Shang, Wang Huang, Shuaiqi Wang

PDF Pages: 1818-1831 Full Text (284) Reporting Checklist Data Sharing Statement COI Form Open Access

Chemoprotective effect of boeravinone B against 1,2-dimethyl hydrazine induced colorectal cancer in rats via suppression of oxidative stress and inflammatory reaction

Caijin Zhou, Wenting Ou, Qingwen Xu, Lin Lin, Feipeng Xu, Rihong Chen, Huilai Miao

PDF Pages: 1832-1841 Full Text (379) Reporting Checklist Data Sharing Statement COI Form Open Access

A novel senescence-associated LncRNA signature predicts the prognosis and tumor microenvironment of patients with colorectal cancer: a bioinformatics analysis

Enmin Huang, Tao Ma, Junyi Zhou, Ning Ma, Weisheng Yang, Chuangxiong Liu, Zehui Hou, Shuang Chen, Zhen Zong, Bing Zeng, Yingru Li, Taicheng Zhou

PDF Pages: 1842-1863 Full Text (567) Reporting Checklist Data Sharing Statement COI Form Open Access

Characterization of somatic mutations and pathway alterations during hepatocellular carcinoma vascular invasion using next-generation sequencing

Qi Li, Qifan Zhang, Jinzhang Chen, Mengya Zang, Xiaoyun Hu, Rong Li, Jinlin Hou, Jie Zhou

PDF Pages: 1864-1874 Full Text (308) Reporting Checklist Data Sharing Statement COI Form Open Access

CircMMP9 accelerates the progression of hepatocellular carcinoma through the miR-149/CCND2 axis

Xiaolou Li, Jiankai Fang, Guangmin Wei, Ying Chen, Dongliang Li

PDF Pages: 1875-1888 Full Text (323) Reporting Checklist Data Sharing Statement COI Form Open Access

Development of a novel combined nomogram model integrating Rad-score, age and ECOG to predict the survival of patients with hepatocellular carcinoma treated by transcatheter arterial chemoembolization

Aiai Liu, Bo Liu, Xiaodong Duan, Bo Yang, Yiren Wang, Ping Dong, Ping Zhou

PDF Pages: 1889-1897 Full Text (408) Reporting Checklist Data Sharing Statement COI Form Open Access

Anti-PD-1 antibodies plus lenvatinib in patients with unresectable hepatocellular carcinoma who progressed on lenvatinib: a retrospective cohort study of real-world patients

Jixue Zou, Peixin Huang, Ningling Ge, Xin Xu, Yanhong Wang, Lan Zhang, Yi Chen

PDF Pages: 1898-1906 Full Text (416) Reporting Checklist Data Sharing Statement COI Form Open Access

Study on efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with regorafenib and PD-1 antibody versus continued TACE combined with regorafenib in patients with hepatocellular carcinoma after failed second-line treatment with regorafenib

Haochen Wang, Weizhong Xiao, Yanjing Han, Shasha Cao, Zhiyuan Zhang, Guang Chen, Yuefeng Hu, Long Jin

PDF Pages: 1907-1914 Full Text (405) Reporting Checklist Data Sharing Statement COI Form Open Access

Bioinformatic-based mechanism identification of E2F1-related ceRNA and E2F1 immunoassays in hepatocellular carcinoma

Wenlei Dong, Chao Zhan

PDF Pages: 1915-1926 Full Text (544) Reporting Checklist COI Form Open Access

A novel biomarker NIFK-AS1 promotes hepatocellular carcinoma cell cycle progression through interaction with SRSF10

Huibin Song, Wenjing Li, Sixuan Guo, Zhentao He, Shi Liu, Yongsheng Duo

PDF Pages: 1927-1941 Full Text (362) Reporting Checklist Data Sharing Statement COI Form Open Access

Bioinformatics analysis of immune infiltrates and tripartite motif (TRIM) family genes in hepatocellular carcinoma

Jun Cao, Bingbing Su, Rui Peng, Hao Tang, Daoyuan Tu, Yuhong Tang, Jie Zhou, Guoqing Jiang, Shengjie Jin, Qian Wang, Aoqing Wang, Renjie Liu, Qiangwei Deng, Chi Zhang, Dousheng Bai

PDF Pages: 1942-1958 Full Text (485) Reporting Checklist COI Form Open Access

The role of tumor-infiltrating B cells in the tumor microenvironment of hepatocellular carcinoma and its prognostic value: a bioinformatics analysis

Jixue Zou, Chubin Luo, Haoyang Xin, Tongchun Xue, Xiaoying Xie, Rongxin Chen, Lan Zhang

PDF Pages: 1959-1966 Full Text (539) Reporting Checklist Data Sharing Statement COI Form Open Access

Association between progression-free survival and metal stent patency in patients with advanced pancreatic cancer

Jinwoo Ahn, Dong-Won Ahn, Jaewoo Park, Kwangrok Jung, Jong-Chan Lee, Jin-Hyeok Hwang, Ji Bong Jeong, Jaihwan Kim

PDF Pages: 1981-1988 Full Text (252) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A phase II trial of gemcitabine and erlotinib followed by ChemoProton therapy plus capecitabine and oxaliplatin for locally advanced pancreatic cancer

Samrat M. Sanghvi, Alex R. Coffman, Chung-Tsen Hsueh, Joseph Kang, Annie Park, Naveenraj L. Solomon, Carlos A. Garberoglio, Mark E. Reeves, Jerry D. Slater, Gary Y. Yang

PDF Pages: 1989-1996 Full Text (284) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinicopathological prognostic factors for gallbladder carcinoma: a retrospective study

Fátima Ramalhosa, Maria João Amaral, Marco Serôdio, Rui Caetano Oliveira, Paulo Teixeira, Maria Augusta Cipriano, José Guilherme Tralhão

PDF Pages: 1997-2006 Full Text (347) Reporting Checklist Data Sharing Statement COI Form Open Access

Review Article

A narrative review of the evolving role of immunotherapy in the management of esophageal and gastric cancer

Ankit Madan, Hope E. Uronis, John H. Strickler

PDF Pages: 2007-2019 Full Text (550) Reporting Checklist COI Form Open Access

Let food be thy medicine: the role of diet in colorectal cancer: a narrative review

Ying Zheng, Lingnan Meng, Hao Liu, Lijuan Sun, Yongzhan Nie, Qiong Wu, Daiming Fan, Mengbin Li

PDF Pages: 2020-2032 Full Text (585) Reporting Checklist COI Form Open Access

The evolving treatment paradigm of locally advanced rectal cancer: a narrative review

Muhammad Awawda, Tarek Taha, Saeed Salman, Salem Billan, Adham Hijab

PDF Pages: 2033-2047 Full Text (288) Reporting Checklist Peer Review File COI Form Open Access

Research progress on microRNAs as molecular markers in pancreatic cancer: a narrative review

Rui-Biao Fu, Xi Chen, Yan Chen, Qing-Huang Ye, Bin Yang, Qian Shao, Jin-Hui Zhu

PDF Pages: 2048-2056 Full Text (286) Reporting Checklist COI Form Open Access

Case Report

Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, TP53, SMAD4 and a potential role of the PI3K-AKT and EGFR pathways: a case report

Miguel Cordova-Delgado, Mauricio P. Pinto, Gonzalo Pizarro, Elard Koch, Cristian Vargas, Mauricio Hernández, Guillermo Nourdin, Pablo Saldivia, Maria Paz Rodriguez Z., Alejandro Berkovits, Patricio Manque, Juvenal A. Rios, Benjamin Garcia-Bloj, Marcelo Garrido

PDF Pages: 2057-2064 Full Text (412) Reporting Checklist COI Form Open Access

Multiple interventional embolizations for hemostasis in hemorrhage following advanced colorectal cancer treatment: a case report

Dongqiang Yang, Bo Shi, Yazhou Li, Yu Zhao, Ping Shi, Zhigang Li

PDF Pages: 2065-2071 Full Text (271) Reporting Checklist COI Form Open Access

Original Article

The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal

Umashankar K Ballehaninna, Ronald S Chamberlain

Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity

Dongyun Yang, Andrew Hendifar, Cosima Lenz, Kayo Togawa, Felicitas Lenz, Georg Lurje, Alexandra Pohl, Thomas Winder, Yan Ning, Susan Groshen, Heinz-Josef Lenz

Review Article

Imaging of pancreatic cancer: An overview

Pavan Tummala, Omer Junaidi, Banke Agarwal

Immunohistochemical features of the gastrointestinal tract tumors

Hannah H. Wong, Peiguo Chu

Techniques of hepatic resection

Robert J. Aragon, Naveenraj L. Solomon

Gastric cancer: Classification, histology and application of molecular pathology

Bing Hu, Nassim El Hajj, Scott Sittler, Nancy Lammert, Robert Barnes, Aurelia Meloni-Ehrig

HDR brachytherapy for anal cancer

Peter Niehoff, Gyoergy Kovács

Colorectal carcinoma: Pathologic aspects

Matthew Fleming, Sreelakshmi Ravula, Sergei F. Tatishchev, Hanlin L. Wang

Review Articles

Assessment of clinical benefit and quality of life in patients undergoing cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for management of peritoneal metastases

Yue Zhu, Nader Hanna, Cherif Boutros, H. Richard Alexander, Jr.

Original Article

The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal

Umashankar K Ballehaninna, Ronald S Chamberlain

Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity

Dongyun Yang, Andrew Hendifar, Cosima Lenz, Kayo Togawa, Felicitas Lenz, Georg Lurje, Alexandra Pohl, Thomas Winder, Yan Ning, Susan Groshen, Heinz-Josef Lenz

Insulin caused drug resistance to oxaliplatin in colon cancer cell line HT29

Jiezhong Chen, Xu-Feng Huang, Liang Qiao, Andrew Katsifis

Exosome can prevent RNase from degrading microRNA in feces

Yoshikatsu Koga, Masahiro Yasunaga, Yoshihiro Moriya, Takayuki Akasu, Shin Fujita, Seiichiro Yamamoto, Yasuhiro Matsumura

Multicenter evaluation of the safety and efficacy of radioembolization in patients with unresectable colorectal liver metastases selected as candidates for ⁹⁰Y resin microspheres

Andrew S. Kennedy, David Ball, Steven J. Cohen, Michael Cohn, Douglas M. Coldwell, Alain Drooz, Eduardo Ehrenwald, Samir Kanani, Steven C. Rose, Charles W. Nutting, Fred M. Moeslein, Michael A. Savin, Sabine Schirm, Samuel G. Putnam III, Navesh K. Sharma, Eric A. Wang

Treatment of locally advanced unresectable pancreatic cancer: a 10-year experience

Nadia K Malik, Kilian Salerno May, Rameela Chandrasekhar, Wen Wee Ma, Leayn Flaherty, Renuka Iyer, John Gibbs, Boris Kuvshinoff, Gregory Wilding, Graham Warren, Gary Y Yang

Endoscopic stenting versus operative gastrojejunostomy for malignant gastric outlet obstruction-a systematic review and meta-analysis of randomized and non-randomized trials

Vinayak Nagaraja, Guy D. Eslick, Michael R. Cox

Self-expanding metal stents (SEMS) provide superior outcomes compared to plastic stents for pancreatic cancer patients undergoing neoadjuvant therapy

Megan A. Adams, Michelle A. Anderson, James D. Myles, Shokoufeh Khalatbari, James M. Scheiman

Review Article

Gastric cancer: Classification, histology and application of molecular pathology

Bing Hu, Nassim El Hajj, Scott Sittler, Nancy Lammert, Robert Barnes, Aurelia Meloni-Ehrig

Colorectal carcinoma: Pathologic aspects

Matthew Fleming, Sreelakshmi Ravula, Sergei F. Tatishchev, Hanlin L. Wang

Diet and supplements and their impact on colorectal cancer

Marinos Pericleous, Dalvinder Mandair, Martyn E. Caplin

HIFU for palliative treatment of pancreatic cancer

Tatiana D. Khokhlova, Joo Ha Hwang

Gastrointestinal stromal tumor

Xiaohui Zhao, Changjun Yue

Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features

Marnelli A. Bautista-Quach, Christopher D. Ake, Mingyi Chen, Jun Wang

Imaging of pancreatic cancer: An overview

Pavan Tummala, Omer Junaidi, Banke Agarwal

Preoperative imaging for hepatic resection of colorectal cancer metastasis

Timothy L. Frankel, Richard Kinh Gian Do, William R. Jarnagin

Techniques of hepatic resection

Robert J. Aragon, Naveenraj L. Solomon

Liver-directed therapies in metastatic colorectal cancer

Margaret E. Clark, Richard R. Smith

Imaging preoperatively for pancreatic adenocarcinoma

Jason Alan Pietryga, Desiree E. Morgan

Immunohistochemical features of the gastrointestinal tract tumors

Hannah H. Wong, Peiguo Chu

Current and future systemic treatment options in metastatic pancreatic cancer

Cagatay Arslan, Suayib Yalcin

Radioembolization of hepatic tumors

Andrew Kennedy

FDG PET imaging in the staging and management of gastric cancer

Shane Hopkins, Gary Y Yang

Stereotactic body radiation therapy for liver metastases

Marta Scorsetti, Elena Clerici, Tiziana Comito

The role of epithelial-mesenchymal transition in pancreatic cancer

Jen-Jung Pan, Muh-Hwa Yang

Surgical management of gastric cancer: the East vs. West perspective

Maki Yamamoto, Omar M. Rashid, Joyce Wong

Human papillomavirus tumor infection in esophageal squamous cell carcinoma

Ethan B. Ludmir, Sarah J. Stephens, Manisha Palta, Christopher G. Willett, Brian G. Czito

Molecular pathology of pancreatic neuroendocrine tumors

Mingyi Chen, Michael Van Ness, Yangtong Guo, Jeffrey Gregg

Immunotherapy for advanced gastric and esophageal cancer: preclinical rationale and ongoing clinical investigations

Alexander G. Raufi, Samuel J. Klempner

Original Articles

Forthcoming prognostic markers for esophageal cancer: a systematic review and meta-analysis

Vinayak Nagaraja, Guy D. Eslick

Review Articles

Understanding and targeting resistance to anti-angiogenic therapies

Jeffrey M. Clarke, Herbert I. Hurwitz

Markers of resistance to anti-EGFR therapy in colorectal cancer

Walid Shaib, Reena Mahajan, Bassel El-Rayes

Original Article

Bax expression is a candidate prognostic and predictive marker of colorectal cancer

Venkat R Katkoori, Catalina Suarez-Cuervo, Chandrakumar Shanmugam, Nirag C Jhala, Tom Callens, Ludwine Messiaen, James Posey III, Harvey L Bumpers, Sreelatha Meleth, William E Grizzle, Upender Manne

Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity

Dongyun Yang, Andrew Hendifar, Cosima Lenz, Kayo Togawa, Felicitas Lenz, Georg Lurje, Alexandra Pohl, Thomas Winder, Yan Ning, Susan Groshen, Heinz-Josef Lenz

The influence of radiation therapy dose escalation on overall survival in unresectable pancreatic adenocarcinoma

William A. Hall, Lauren E. Colbert, Dana Nickleach, Jeffrey Switchenko, Yuan Liu, Theresa Gillespie, Joseph Lipscomb, Claire Hardy, David A. Kooby, Roshan S. Prabhu, John Kauh, Jerome C. Landry

Overall survival analysis of neoadjuvant chemoradiotherapy and esophagectomy for esophageal cancer

Faisal A. Siddiqui, Katelyn M. Atkins, Brian S. Diggs, Charles R. Thomas Jr, John G. Hunter, James P. Dolan

Radiotherapy patterns of care in gastric adenocarcinoma: a single institution experience

Jessica Cheng, Malcolm H. Squires III, John L. Mikell, Sarah B. Fisher, Charles A. Staley III, David A. Kooby, Bassel F. El-Rayes, Walter J. Curran Jr, William A. Hall, Lauren E. Colbert, Joseph W. Shelton, Shishir K. Maithel, Jerome Landry, David S. Yu

Impact of intensity modulated radiation therapy on survival in anal cancer

Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Sibo Tian, Richard J. Cassidy, Theresa Gillespie, Pretesh R. Patel, Jerome C. Landry, Kirtesh R. Patel

Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy

Chongkai Wang, Jun Gong, Travis Y. Tu, Peter P. Lee, Marwan Fakih

Palliative care and end-of-life health care utilization in elderly patients with pancreatic cancer

Nizar Bhulani, Arjun Gupta, Ang Gao, Jenny Li, Chad Guenther, Chul Ahn, Elizabeth Paulk, Stephanie Houck, Muhammad S. Beg

Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum

Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Pérez-Irizarry, Charles H. Cha, Caroline H. Johnson, Daniel J. Boffa, Dale Han, Kimberly L. Johung, Yawei Zhang, Sajid A. Khan

Review Article

Alcoholic liver disease- Hepatocellular carcinoma transformation

Samuel W French, James Lee, Jim Zhong, Timothy R Morgan, Virgil Buslon, William Lungo, Barbara A French

Pancreatic adenocarcinoma pathology: changing “landscape”

Lodewijk A. A. Brosens, Wenzel M. Hackeng, G. Johan Offerhaus, Ralph H. Hruban, Laura D. Wood

Refining the management of resectable esophagogastric cancer: FLOT4, CRITICS, OE05, MAGIC-B and the promise of molecular classification

Jeremy Chuang, Jun Gong, Samuel J. Klempner, Yanghee Woo, Joseph Chao

Original Articles

Socioeconomic status, p53 abnormalities, and colorectal cancer

Emily Vogtmann, Chandrakumar Shanmugam, Venkat R. Katkoori, John Waterbor, Upender Manne

Nab-paclitaxel monotherapy in refractory pancreatic adenocarcinoma

Parvin F. Peddi, May Cho, Jian Wang, Feng Gao, Andrea Wang-Gillam

Below are the latest Journal of Gastrointestinal Oncology articles published online ahead of print publication.

Original Article

A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patients

Sarah Obuya, Amr Elkholy, Nagavardhini Avuthu, Michael Behring, Prachi Bajpai, Sumit Agarwal, Hyung-Gyoon Kim, Nefertiti El-Nikhely, Pamela Akinyi, James Orwa, Farrukh Afaq, Mohammed Abdalla, Anwar Michael, Mohamed Farouk, Lori Brand Bateman, Mona Fouad, Mansoor Saleh, Chittibabu Guda, Upender Manne, Waleed Arafat

The clinical effect of conversion surgery for advanced gastric cancer patients with peritoneal metastasis

Masayuki Shinkai, Motohiro Imano

Analysis of blood markers for early colorectal cancer diagnosis

Juan Bayo Calero, Miguel Angel Castaño López, Pedro Germán Casado Monge, Jacobo Díaz Portillo, Ana Bejarano García, Francisco Navarro Roldán

Cost-effectiveness of screening with polymerase chain reaction for Helicobacter pylori to prevent gastric cancer and peptic ulcers

Aaron Oh, Han Truong, Judith Kim, Sheila D. Rustgi, Julian A. Abrams, Chin Hur

Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells

Xianpeng Shi, Pengchong Wang, Yaning Zhu, Li Li, Tongfei Yang, Jingying Sun, Langchong He, Nan Zhou, Peng Zhang

Collagen XV mediated the epithelial-mesenchymal transition to inhibit hepatocellular carcinoma metastasis

Ting Yao, Weiwei Hu, Jinmei Chen, Leer Shen, Yongsheng Yu, Zhenghao Tang, Guoqing Zang, Yi Zhang, Xiaohua Chen

Effect of the systemic immune-inflammation index on postoperative complications and the long-term prognosis of patients with colorectal cancer: a retrospective cohort study

Liping Feng, Ruimin Xu, Lin Lin, Xianghui Liao

Survival comparison of stage IIA rectal cancer with or without neoadjuvant therapy: a SEER database analysis with propensity score matching

Han Yan, Peng-Yuan Wang, Ying-Chao Wu, Yu-Cun Liu

Development and validation of a nomogram based on neutrophil-to-lymphocyte ratio and fibrinogen-to-lymphocyte ratio for predicting recurrence of colorectal adenoma

Qijin He, Sanjun Du, Xu Wang, Jiani Liu, Xin Xu, Wentian Liu, Jie Zhang, Kui Jiang

Role of local therapy in the management of patients with metastatic anal squamous cell carcinoma: a National Cancer Database study

Rami P. Atallah, Yining Zhang, Katerina Zakka, Renjian Jiang, Zhonglu Huang, Walid L. Shaib, Maria Diab, Mehmet Akce, Christina Wu, Bassel F. El-Rayes, Olatunji B. Alese

Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway

Akshay Pratap, Anqi Li, Lindsey Westbrook, Anna K. Gergen, Sanchayita Mitra, Argudit Chauhan, Linling Cheng, Michael J. Weyant, Martin McCarter, Sachin Wani, Robert Alexander Meguid, John D. Mitchell, Mitchell Cohen, David Fullerton, Xianzhong Meng

Clinical features of biliary tract cancer in Japanese individuals with Lynch syndrome

Nobuhiko Kanaya, Hideki Aoki, Toshiaki Morito, Fumitaka Taniguchi, Kunitoshi Shigeyasu, Chieko Tamura, Kokichi Sugano, Kiwamu Akagi, Hideyuki Ishida, Kohji Tanakaya

Prognostic risk factors for postoperative long-term outcomes in elderly stage IA gastric cancer patients

Yoshihiko Kakiuchi, Shinji Kuroda, Satoru Kikuchi, Shunsuke Kagawa, Toshiyoshi Fujiwara

Review Article

Inflammatory bowel disease-associated malignancies and considerations for radiation impacting bowel: a scoping review

Shari Bodofsky, Robert H. Freeman, Sean S. Hong, Anupama Chundury, Lara Hathout, Matthew P. Deek, Salma K. Jabbour

Challenges in the diagnosis of marginal zone lymphoma with symptoms of small intestinal disease: a case report and scoping review of the literature

Konstantinos Markopoulos, Emanuel Bührer, Yara Banz, Heather Dawson, Swantje Engelbrecht, Manfred Essig, Benjamin Misselwitz

Letter to the Editor

Platelet lymphocyte ratio and sarcopenia were associated with survival after hepatocellular carcinoma undergoing curative resection

Xuping Feng, Qingbo Feng, Jiaxin Li

Is D2 laparoscopic gastrectomy essential for elderly patients with advanced gastric cancer?—reply letter

Masazumi Sakaguchi

Liver transplantation for cholangiocarcinoma: exploring a new land

Lin-Feng He, Tao Lv, Yong-Fa Huang, Yao Xiao, Gang Xu, Jia-Yin Yang

Was ulcerative colitis one of the risk factors of colorectal cancer?

Qiaoqiao Guo, Qiaoyang Xu, Xiangjin Zhu, Yinghong Guo, Jiangfeng Wu

Is D2 laparoscopic gastrectomy essential for elderly patients with advanced gastric cancer?

Qingbo Feng, Tao Zhang, Ming Xie

Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol

Brady S. Laughlin, Jonathan B. Ashman, William G. Rule, Nathan Y. Yu, Terence T. Sio

Resection and thermal hepatic ablation of pancreatic neuroendocrine tumor liver metastases for prolonged survival

Xindi Ke, Huayu Yang

Radiofrequency ablation has similar short-term effects but significantly lowers the long-term effect compared with routine resection in the treatment of small hepatocellular carcinoma

Penglei Ge, Yang Wu, Lin Li

Case Report

Massive pancreatic serous cystadenomas raise important questions regarding surgical management of incidental pancreatic cystic lesions: a report of two cases

Samuel Chiacchia, Robert Blue, Zahra Shafaee

A fatal primary gastric melanoma treated by a double immunotherapy with ipilimumab/nivolumab: description of a case report

Raffaele Longo, Sebastien Colin, Camille Streiff, Chloé Wendel, Axelle Bonhomme, Claudia Sava, Marco Campitiello, Francesca Plastino, Julie Egea

Anti-OJ antibody-positive anti-synthetase syndrome with repeated arthritis, fever, and recurrent liver cancer: a case report

Ji-Na Gu, Wang Yan, Qiao-Ling Gao, Lin Chen

Preliminary experience of oral fruquintinib-capecitabine as a new maintenance treatment strategy for advanced colorectal cancer in the era of coronavirus disease 2019 (COVID-19): case report and literature review

Ming Quan, Zhiqin Chen, Jingde Chen, Yanan Hai, Yong Gao

Long-term outcome of metachronous, multiple, early Epstein-Barr virus-associated gastric carcinoma: a case report

Yoichi Tanaka, Takayuki Tajima, Hiroshi Kajiwara, Tomoko Sugiyama, Tomoki Nakamura, Tomoko Hanashi, Osamu Chino, Hiroyasu Makuuchi

Conversion surgery by hand-assisted laparoscopic surgery following chemotherapy for rectal cancer with H3 liver metastases: a case report

Takayuki Tajima, Masaya Mukai, Shuji Uda, Hideki Izumi, Daiki Yokoyama, Sayuri Hasegawa, Hiroyasu Makuuchi

Anorectal manometry after rectal surgery: a case report with rectal bleeding and perforation

Jin Zhao, Mei Hu, Hong Yang, Dongping Zhang, Jie Yang, Qi Liu

Journal highlight more

Journal of Gastrointestinal Oncology is an open-access, international peer-reviewed journal indexed by PubMed/PubMed Central, Science Citation Index Expanded (SCIE), with a focus on the diagnosis, prevention and clinical investigations of gastrointestinal cancer, including but not limited to, multimodality therapy, markers, imaging and tumor biology.