Appendiceal diverticulosis: a harbinger of underlying primary appendiceal adenocarcinoma?
Case Report

Appendiceal diverticulosis: a harbinger of underlying primary appendiceal adenocarcinoma?

Jia Lin Ng1, Shing Lih Wong2, Ronnie Mathew1

1Department of Colorectal Surgery, 2Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore

Correspondence to: Jia Lin Ng. Department of Colorectal Surgery, Singapore General Hospital, 20 College Road, 169856, Singapore. Email: ng.jia.lin@singhealth.com.sg.

Abstract: Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base. During laparoscopic appendicectomy, the appendiceal phlegmon was adhered to the surrounding bowel. Histology showed a perforated diverticulum near the appendiceal tip, and a primary appendiceal well-differentiated adenocarcinoma located proximal to it with clear margins. Up to 48% of ADs are associated with appendiceal neoplasms, but its coexistence with PAA is reported in fewer than ten instances worldwide. Obstructing appendiceal tumours, by raising intraluminal pressure, can predispose to AD formation. Intestinal-type PAA is often managed like its colorectal counterpart, although controversies about management of PAA in a perforated AD remain. Recognition of the association of AD and PAA is critical to ensure meticulous oncological resection and histological examination.

Keywords: Appendix cancer; appendiceal diverticular disease; diverticulosis; case report


Submitted Jul 15, 2017. Accepted for publication Aug 21, 2017.

doi: 10.21037/jgo.2017.08.18


Introduction

Primary appendiceal adenocarcinoma (PAA) is a rare entity, accounting for 0.5% of all gastrointestinal malignancies (1). While colonic diverticular is common, acquired appendiceal diverticulosis (AD) is rare, found in 0.004–2.1% of all appendectomies, and 0.2–0.66% of autopsy specimens (2,3). Their co-existence is extremely uncommon, with fewer than 10 case reports and case series worldwide (Table 1) (4-10). Some authors have postulated a correlation between the formation of AD and space-occupying appendiceal lesions that raise intra-luminal pressure (2,8,11,12). Is the presence of an appendiceal diverticulum a harbinger of an often silent but sinister appendiceal tumour?

Table 1
Table 1 Review of literature of concomitant AD and PAA
Full table

Case presentation

A middle-aged Chinese male presented to the emergency department of a tertiary hospital with five days duration of right iliac fossa (RIF) pain and anorexia. There was no fever, nausea or vomiting. Medical comorbidities include hypertension, dyslipidemia, peripheral vascular disease, chronic alcoholism and 30 pack years smoking history. No family history of malignancy was noted. Clinical examination revealed a localised tender RIF mass, and a normal digital rectal examination. Haemoglobin was 13.4 g/dL, leucocytosis 12.6×109/L with neutrophil left shift, and carcinoembryonic antigen was 3.5 µG/L. Contrasted abdominal computerised tomography (CT) scan (Figure 1) demonstrated a thickened appendix with 3 cm abscess at its base. There was no local or distant evidence of tumour. A diagnosis of acute perforated appendicitis was made, with a differential diagnosis of appendiceal diverticulitis.

Figure 1 CT scan of abdomen demonstrating peri-appendiceal abscess with perforated appendicitis.

Emergency laparoscopic appendicectomy was performed. An appendiceal phlegmon was found densely adhered to the caecum and terminal ileum, without free perforation or intra-peritoneal disease. The appendiceal base was thickened and the caecal defect was closed with Vicryl stitches following appendicectomy (Figure 2). Histopathological examination showed an 8 cm long appendix, with a perforated acquired diverticulum near the appendiceal tip, associated with surrounding acute inflammation (Figure 3). There was an 8 mm well-differentiated PAA located 1 cm proximal to the tip, which was not perforated but had invaded the muscularis propria (Figure 4). Margins were clear and the base of the appendix was uninvolved by cancer. Final stage according to the American Joint Committee on Cancer 7th edition guidelines (13) was T2 Nx M0, with no lymph nodes harvested.

Figure 2 Intra-operative laparoscopic image of appendiceal phlegmon.
Figure 3 Acquired diverticulum at the appendiceal tip with deficient muscularis propria (black arrow). (H & E stain, low power, magnification x2).
Figure 4 Well-differentiated appendiceal adenocarcinoma (black arrow) arising adjacent to normal appendiceal mucosa. (H & E stain, low power, magnification x4).

Post-operative recovery was unremarkable, and he was discharged 5 days later. He was advised for completion right hemicolectomy, but declined surgery. Colonoscopy revealed two sub-centimeter benign polyps. Interval CT scan 4 months later showed no metastatic disease or local recurrence.


Discussion

Early diagnosis of PAA is difficult, and most are discovered incidentally or present acutely with appendicitis (1,14-16). In this case, PAA was diagnosed due to a separate perforated AD. This may not be entirely fortuitous as recent literature (2,8,11,12) has suggested that the presence of an AD may herald an often silent appendiceal neoplasm. While most of these are benign, it becomes especially clinically pertinent when they harbour malignant pathologies.

AD is rare, occurring in 0.004–2.1% of appendectomies (2,3). ADs are false diverticula caused by mucosal herniation through the deficient muscularis propria. Raised intraluminal pressure may predispose to its formation, with luminal obstruction caused by benign inflammation, stricture, faecolith, polyps or mucin (3).

AD is associated with underlying appendiceal neoplasms in 7.1% to 48% of cases (8,11-13). Lamps et al. (11) reported a 42% association between low-grade appendiceal mucinous neoplasms and AAD, which was statistically significant compared to the respective incidences of these neoplasms and diverticula in the literature. Of 1,361 routine appendicectomy specimens, Dupre et al. (8) discovered 23 with AD, and 11 (48%) of these with concomitant appendiceal neoplasm, including carcinoids, mucinous adenomas, tubular adenomas and adenocarcinomas.

The relationship between AD and PAA is relatively unknown, and has been previously described in seven instances, of which four were in non-English journals (Table 1) (4-7), and two were described 50 to 100 years ago (Table 1) (9,10). PAA is also rare, accounting for 0.5% of all gastrointestinal malignancies, with an age-adjusted incidence of 0.12 cases per 1,000,000 people per year (17-19). Among appendiceal malignancies, 70% are carcinoids, 20% are cystadenocarcinomas and 10% are adenocarcinomas. Among adenocarcinomas, mucinous type (55%) is most common, often presenting with mucoceles or pseudomyxoma peritonei. This is followed by intestinal-type (34%) and adenocarcinoid type (11%). Each subtype varies in staging, management and prognosis.

The optimal management of intestinal-type PAA remains controversial, and guidelines are sparse. Right hemicolectomy is generally advocated as the preferred oncological intervention (17-24). Many studies demonstrate survival benefit of right hemicolectomies over appendectomies because the incidence of lymph node involvement is 66.7%. Right hemicolectomy led to upstaging of cancer in 38% of cases in Nitecki’s paper (1). This translates to a 73% 5-year survival rate in the right hemicolectomy group compared to 44% in the appendicectomy group, corresponding to the Surveillance, Epidemiology, and End Results database from 1973 to 2007, which showed a 55% 5-year survival (19). Smaller studies have suggested that appendicectomy may suffice for a highly-selected group of well-differentiated adenocarcinoma confined to the mucosa (23).

The role of chemotherapy is poorly understood. Extrapolating from colorectal cancer data, systemic with or without intraperitoneal chemotherapy may be used in the presence of nodal involvement. Controversy remains in those without nodal involvement, especially in perforated appendicitis or diverticulitis without gross malignant cell spillage. Might one presume that the cancer biology is similar to that of an obstructed colonic tumour with upstream colonic perforation? Nitecki (1) could not show a statistically-significant 5-year survival superiority when comparing perforated and non-perforated intestinal-type adenocarcinomas (39% versus 43%), postulating that there could be a decreased risk of peritoneal implantation in spilled appendiceal malignant cells compared its colonic counterpart.

Despite its rarity, recognising the association of AD and PAA has profound implications for surgeons and pathologists. In cases where malignancy is suspected pre-operatively or intra-operatively, and a grossly abnormal lesion is found, frozen section can be performed. We propose that a diagnosis of PAA of stage T2 and above is sufficient grounds (24) to proceed to a definitive right hemicolectomy in the same sitting, sparing the patient from repeated surgery.

As it may be difficult to differentiate acute inflammatory appendicitis and appendiceal neoplasms pre-operatively, surgeons should endeavour for atraumatic en-bloc appendectomies and avoid piece-meal removal. Some centres advocate dissecting the mesoappendix close to the appendiceal specimen, leaving the mesoappendix behind (25,26). We propose that surgeons should remove the entire mesoappendix to assess regional appendiceal lymphatic involvement (16).

Pathologists should recognise that up to half of AD may harbour a space-occupying lesion, which are easily missed if small: Dupre (8) described one case with concomitant AD and PAA which had a tiny focus of adenocarcinoma and was undiagnosed on initial routine representative sampling. Unlike its mucinous counterpart, intestinal-type adenocarcinomas rarely secrete mucin and are thus easily missed. Regular routine slicing involves longitudinal bisectioning at the base, middle and tip of the appendix, which may be insufficient (2). The presence of AD should prompt thorough, if not complete, histopathological examination of the entire appendectomy specimen.

To conclude, AD, though rare, is a harbinger of underlying appendiceal lesions that cause intraluminal hypertension. Both gastrointestinal surgeons and pathologists should be cognisant of its association with appendiceal neoplasms, especially malignant ones like PAA.


Acknowledgements

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Informed Consent: Written informed consent was obtained from the patient for publication of this manuscript and its accompanying images.


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Cite this article as: Ng JL, Wong SL, Mathew R. Appendiceal diverticulosis: a harbinger of underlying primary appendiceal adenocarcinoma? J Gastrointest Oncol 2018;9(2):E1-E5. doi: 10.21037/jgo.2017.08.18