We thank Guo et al. for their comments on our published article “Secondary colon cancer in patients with ulcerative colitis: a systematic review and meta-analysis” (1).
After verification, the interpretation of P<0.00001 is significantly different, so it is concluded that there is a relationship between colon cancer and colitis (2). After consideration, in prospective studies, such as cohort studies and randomized controlled trial (RCT), not only relative risk (RR) but also odds ratio (OR) can be calculated (3). Generally, RR is used in many cohort studies and RCT when reporting the results. However, the overall rate of this study is low, so OR is similar to RR, and so it is correct to use OR.
Funding: The present work was supported by the National Natural Science Foundation of China (No. 81470826), the Science Foundation from Science & Technology Department of Sichuan Province (No. 2019YFS0262; No. 2020YFS0410; No. 22ZDYF1691; No. 2018FZ0062) and 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD18023).
Provenance and Peer Review: This article was a standard submission to the journal. The article did not undergo external peer review.
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-22-264/coif). The authors have no conflicts of interest to declare.
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- Guo Q, Xu Q, Zhu X, et al. Was ulcerative colitis one of the risk factors of colorectal cancer? J Gastrointest Oncol 2022;13:3340.
- Shivakumar BM, Lakshmankumar B, Rao L, et al. Colorectal neoplasia in long-standing ulcerative colitis - a prospective study from a low-prevalence area. Colorectal Dis 2013;15:e462-8. [Crossref] [PubMed]
- Hilmi I, Singh R, Ganesananthan S, et al. Demography and clinical course of ulcerative colitis in a multiracial Asian population: a nationwide study from Malaysia. J Dig Dis 2009;10:15-20. [Crossref] [PubMed]