TY - JOUR AU - Ludmir, Ethan B. AU - Stephens, Sarah J. AU - Palta, Manisha AU - Willett, Christopher G. AU - Czito, Brian G. PY - 2015 TI - Human papillomavirus tumor infection in esophageal squamous cell carcinoma JF - Journal of Gastrointestinal Oncology; Vol 6, No 3 (June 01, 2015): Journal of Gastrointestinal Oncology Y2 - 2015 KW - N2 - The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage. Here, we review these analyses and attempt to provide a clinically-relevant overview of HPV infection in ESCC. HPV-ESCC detection rates are highly variable across studies. Geographic location likely accounts for a majority of the variation in HPV prevalence, with high-incidence regions including Asia reporting significantly higher HPV-ESCC infection rates compared with low-incidence regions such as Europe, North America, and Oceania. Based on our examination of existing data, the current literature does not support the notion that HPV is a prominent carcinogen in ESCC. We conclude that there is no basis to change the current clinical approach to ESCC patients with respect to tumor HPV status. UR - https://jgo.amegroups.org/article/view/3988