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Timing of surgery following neoadjuvant chemoradiation in rectal cancer: a retrospective analysis from an academic medical center

  
@article{JGO27585,
	author = {Seth Maliske and Justin Chau and Timothy Ginader and John Byrn and Sudershan Bhatia and Andrew Bellizzi and Daniel J. Berg and Varun Monga},
	title = {Timing of surgery following neoadjuvant chemoradiation in rectal cancer: a retrospective analysis from an academic medical center},
	journal = {Journal of Gastrointestinal Oncology},
	volume = {10},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: Neoadjuvant chemoradiotherapy (nCRT) has been shown to achieve decreased local recurrence (LR) with lower toxicity in rectal cancer patients, but data confirming the optimal timing of surgery following this therapy is less robust.
Methods: The University of Iowa Cancer Registry was queried to identify all patients with stages  II–III rectal cancer who received nCRT and surgery from 2000 through 2012. Primary endpoints were time interval to surgery (TI), and overall survival (OS). Secondary endpoints included pathologic outcomes, perioperative morbidities and postoperative complications. Patient characteristics and treatment regimens were compared. Univariate Cox proportional hazard models were used to study the association between TI and OS. Associations of TI with secondary endpoints were tested using Chi-square tests of association. 
Results: Eighty-seven patients presented with stages II–III rectal cancer. Mean TI was 9.92 weeks. There was no significant association between TI and OS when comparing },
	issn = {2219-679X},	url = {http://jgo.amegroups.com/article/view/27585}
}