TY - JOUR AU - Shamavonian, Raphael AU - McLachlan, Rohan AU - Fisher, Oliver M. AU - Valle, Sarah J. AU - Alzahrani, Nayef A. AU - Liauw, Winston AU - Morris, David L. PY - 2019 TI - The effect of intraoperative fluid administration on outcomes of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy JF - Journal of Gastrointestinal Oncology; Vol 10, No 2 (April 08, 2019): Journal of Gastrointestinal Oncology Y2 - 2019 KW - N2 - Background: Determine the effect of intraoperative fluids (IOFs) administered during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on postoperative patient outcomes. Methods: Retrospective cohort study of patients that underwent CRS/HIPEC from February 2010 to June 2017. Results: A total of 335 patients formed the cohort study. Patients who received higher IOFs had longer hospital length of stay (LOS) (34 vs . 22.5 days; P vs . 3.2 days; P vs . 23 days; P vs . 3.4 days; P vs . 25.2 days; P=0.04) and longer ICU admission (4.7 vs . 3.6 days; P=0.03). On multivariable analysis, less blood product transfusions demonstrated a decreased LOS in hospital by 4.8 days (P=0.01) and fewer grade 3/4 complications (OR 0.59; 95% CI, 0.35–0.99; P=0.05). Conclusions: Greater IOF administration is associated with an increase in postoperative morbidity, including hospital LOS, ICU admission and grade 3/4 complications, in patients undergoing CRS/HIPEC. UR - https://jgo.amegroups.org/article/view/26413