%0 Journal Article %T The effect of intraoperative fluid administration on outcomes of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy %A Shamavonian, Raphael %A McLachlan, Rohan %A Fisher, Oliver M. %A Valle, Sarah J. %A Alzahrani, Nayef A. %A Liauw, Winston %A Morris, David L. %J Journal of Gastrointestinal Oncology %D 2019 %B 2019 %9 %! The effect of intraoperative fluid administration on outcomes of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy %K %X Background: Determine the effect of intraoperative fluids (IOFs) administered during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on postoperative patient outcomes. Methods: Retrospective cohort study of patients that underwent CRS/HIPEC from February 2010 to June 2017. Results: A total of 335 patients formed the cohort study. Patients who received higher IOFs had longer hospital length of stay (LOS) (34 vs . 22.5 days; P vs . 3.2 days; P vs . 23 days; P vs . 3.4 days; P vs . 25.2 days; P=0.04) and longer ICU admission (4.7 vs . 3.6 days; P=0.03). On multivariable analysis, less blood product transfusions demonstrated a decreased LOS in hospital by 4.8 days (P=0.01) and fewer grade 3/4 complications (OR 0.59; 95% CI, 0.35–0.99; P=0.05). Conclusions: Greater IOF administration is associated with an increase in postoperative morbidity, including hospital LOS, ICU admission and grade 3/4 complications, in patients undergoing CRS/HIPEC. %U https://jgo.amegroups.org/article/view/26413 %V 10 %N 2 %P 235-243 %@ 2219-679X