TY - JOUR AU - Zhu, Rebecca AU - Liu, Fangfang AU - Grisotti, Gabriella AU - PĂ©rez-Irizarry, Javier AU - Cha, Charles H. AU - Johnson, Caroline H. AU - Boffa, Daniel J. AU - Han, Dale AU - Johung, Kimberly L. AU - Zhang, Yawei AU - Khan, Sajid A. PY - 2017 TI - Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum JF - Journal of Gastrointestinal Oncology; Vol 9, No 2 (April 2018): Journal of Gastrointestinal Oncology Y2 - 2017 KW - N2 - Background: Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care. Methods: The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum. Patient demographics, clinical characteristics, and survival were compared. Results: A total of 11,302 gastric GISTs were compared to 398 colon and 393 rectal GISTs. After propensity matching, compared to gastric GISTs, rectal GISTs had improved overall survival (HR =0.695, P=0.0264), while colon GISTs had worse overall survival (HR =1.6, P=0.0005). Surgical treatment for rectal GISTs was more likely to be local excision compared to colonic GISTs (51.1% vs. 8.4%, P vs. 34.0% vs. 55.2%, P Conclusions: Patients with rectal GISTs live longer than those with colon and gastric GISTs, and adjuvant therapy prolongs their survival. Many patients with colon GISTs are treated with adjuvant therapy despite a detrimental effect on survival. Tumor biology of colon and rectal GISTs needs to be better studied to tailor treatment. UR - http://jgo.amegroups.com/article/view/17571