%0 Journal Article %T Prognostic relevance of human papillomavirus infection in anal squamous cell carcinoma: analysis of the national cancer data base %A Jhaveri, Jaymin %A Rayfield, Lael %A Liu, Yuan %A Chowdhary, Mudit %A Cassidy, Richard J. %A Madden, Nicholas A. %A Tanenbaum, Daniel G. %A Gillespie, Theresa W. %A Patel, Pretesh R. %A Patel, Kirtesh R. %A Landry, Jerome C. %J Journal of Gastrointestinal Oncology %D 2017 %B 2017 %9 %! Prognostic relevance of human papillomavirus infection in anal squamous cell carcinoma: analysis of the national cancer data base %K %X Background: To examine the prognostic relevance of human papillomavirus (HPV) infection for anal squamous cell carcinoma (ASCC) patients treated with chemoradiation (CRT) in the National Cancer Data Base (NCDB). Methods: The 2014 NCDB was queried for non-metastatic, histologically confirmed, ASCC patients diagnosed between 2004 and 2013. Patients were required to have HPV status documented in order to be eligible. Patients were then stratified into two groups: HPV+ and HPV−. Univariate analysis (UVA) was performed using the χ 2 test for categorical covariates and ANOVA for numerical covariates. Multivariable analysis (MVA) was performed using Cox proportional hazard model for overall survival (OS). Hazard ratios (HRs) and 95% confidence intervals (CIs) were generated for each covariate. To minimize selection bias, propensity score (PS) weighting was implemented to balance OS related variables between the groups including: age, education level, stage, diagnosis year, insurance type, and agent of chemotherapy. Results: A total of 1,063 patients were eligible. Patients were stratified into HPV+ (n=498, 46.8%) and HPV− (n=565, 53.2%). After PS weighting, MVA for OS showed that for men, HPV infection was associated with better OS (HR: 0.60, 95% CI: 0.38–0.96; P=0.034). However, for women, HPV infection did not significantly influence survival (HR: 1.47, 95% CI: 0.96–2.25; P=0.074). Conclusions: To our knowledge, this is the largest patient series evaluating the impact of HPV infection on OS in patients with anal cancer. We found that HPV infection is associated with a statistically significant better survival for men with ASCC. In contrast, for women, HPV infection did not significantly influence survival. %U https://jgo.amegroups.org/article/view/17319 %V 8 %N 6 %P 998-1008 %@ 2219-679X