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Pacritinib to inhibit JAK/STAT signaling in refractory metastatic colon and rectal cancer

	author = {Thomas Regenbogen and Ling Chen and Kathryn Trinkaus and Andrea Wang-Gillam and Benjamin R. Tan and Manik Amin and Katrina S. Pedersen and Haeseong Park and Rama Suresh and Kian-Huat Lim and Emily Ratchford and Amberly Brown and A. Craig Lockhart},
	title = {Pacritinib to inhibit JAK/STAT signaling in refractory metastatic colon and rectal cancer},
	journal = {Journal of Gastrointestinal Oncology},
	volume = {8},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {Background: Treatment options for patients with refractory colorectal cancer are limited and typically provide a chance of only modest benefit. The goal of this study was to evaluate the benefit of inhibiting the JAK/STAT inflammatory pathway with single agent pacritinib in patients with metastatic refractory colorectal adenocarcinoma. 
Methods: A single arm institutional trial was initiated and enrolled patients with metastatic colorectal cancer refractory to at least two standard lines of treatment. Pacritinib 400 mg daily was administered orally continuously in 28 day cycles. 
Results: The trial was discontinued prior to reaching the planned accrual due to an FDA hold on pacritinib and a lack of treatment benefit. Eleven patients were enrolled and seven were evaluated for response. Median baseline C-reactive protein level was 12.1 (2.1–147) mg/L. One patient had stable disease at eight weeks by RECIST criteria and six progressed. There were no grade 4 or 5 adverse events while patients were on study. The grade 2 and lower AE events experienced were consistent with prior pacritinib trials. 
Conclusions: In seven evaluable patients there were no objective responses. The trial was discontinued prior to completing planned accrual based on a low likelihood that the progression free survival goal of 4 months would be met.},
	issn = {2219-679X},	url = {}