TY - JOUR AU - Raiss, Hanan AU - Amarti, Lamiae El AU - Tigaud, Jean Dominique AU - Layachi, Mohamed AU - Bruyas, Amandine AU - Boutayeb, Saber AU - Errihani, Hassan PY - 2017 TI - Probable paclitaxel-induced pancreatitis: uncommon case report and literature review JF - Journal of Gastrointestinal Oncology; Vol 8, No 6 (December 01, 2017): Journal of Gastrointestinal Oncology Y2 - 2017 KW - N2 - Acute pancreatitis is an inflammatory disorder of the pancreas characterized by upper abdominal pain, nausea, and vomiting, with elevated serum amylase or lipase. Gallstones and alcohol are the two main etiologies; drug-induced pancreatitis is uncommon. Paclitaxel associated with pancreatitis is very rare and since that time, only seven case reports have been published. We report a case of a 54-year-old female who developed an acute pancreatitis after administration of the first cycle of neoadjuvant chemotherapy with paclitaxel (175 mg/m 2 over 3 h) and carboplatin (AUC 6) for ovarian adenocarcinoma. After conservative management, pancreatitis was resolved. The patient received an additional five cycles of carboplatin with no complication. Because Paclitaxel is used in many chemotherapy protocols, it is important for clinicians to be aware that paclitaxel can induce acute pancreatitis, as early diagnosis can be vital. UR - https://jgo.amegroups.org/article/view/15470