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Splenectomy ameliorates hematologic toxicity of hyperthermic intraperitoneal chemotherapy

	author = {Robert D Becher and Perry Shen and John H Stewart and Greg Russell and Joel F Bradley and Edward A Levine},
	title = {Splenectomy ameliorates hematologic toxicity of hyperthermic intraperitoneal chemotherapy},
	journal = {Journal of Gastrointestinal Oncology},
	volume = {2},
	number = {2},
	year = {2011},
	keywords = {},
	abstract = {Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is a promising modality for peritoneal carcinomatosis. Splenectomy is frequently required, however effect upon hematotoxicity is unknown.
Methods: 195 patients undergoing the procedure were evaluated and granulocyte colony stimulating factor administered for white blood cell counts <4.0.
Results: 52% of 195 underwent splenectomy; average white blood cell and platelet nadirs were 6.1,172. Non-splenectomy patients averaged white blood cell nadir 4.6, platelet nadir 164.1. Granulocyte colony stimulating factor administered in 29% of splenectomy, 43% of non-splenectomy (P=0.043).
Conclusion: Splenectomy ameliorates hematotoxicity of hyperthermic intraperitoneal chemotherapy and significantly reduces post-operative granulocyte colony stimulating factor requirements.},
	issn = {2219-679X},	url = {}