The gastrointestinal (GI) tract is an anatomic term used to denote the tubular digestive system and its accessory organs. The pathogenesis and etiology of GI tumors is typically multi-factorial, varies with the specific tumor type, and may involve environmental factors (dietary, low socioeconomic status, cigarette smoking, alcohol use, nutritional deficiencies), host factors (certain precancerous conditions), infection (human papillomavirus, helicobacter pylori), and underlying genetic susceptibility.
The JGO invited Dr. Jun Wang from Loma Linda University to organize a focus issue dedicated to gastrointestinal and liver pathology. This issue is dedicated to the pathologic aspects of commonly encountered GI tumors. Experts in the field offer their perspectives about the histopathology, cytopathology, precursor lesions, and recent advances in molecular pathology, and also provide up-to-date guidance in the application of immunohistochemical and molecular/ genetic testing of commonly encountered GI, liver, and pancreatic tumors, with emphasis on their clinical relevance.