Focused Issue on Evolving Role of Immune-oncology Therapeutics in GI Malignancies

Posted On 2018-07-19 10:15:31

In recent years, we have witnessed immunotherapy-based agents transform how we manage patient’s malignant melanoma, non-small cell lung cancer, genitourinary cancers, head and neck cancers and Hodgkin’s lymphoma to list a few. Unfortunately, the progress of immunotherapy-based agents in GI cancers has been slow, although in 2017 we have seen approval of (I) Nivolumab/Pembrolizumab for patients with metastatic CRC with high microsatellite instability (MSI-H) or DNA mismatch repair deficiency (dMMR), (II) Pembrolizumab for patients with advanced gastric and GE junction tumors, who have failed at least two lines of chemotherapy and express PD-L1 protein, (III) Nivolumab for the treatment of patients with HCC following prior sorafenib, regardless of PD-L1 status.

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