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Editorial

Open surgical treatment for esophageal cancer: transhiatal vs. transthoracic, does it really matter?
Uriel Clemente-Gutiérrez, Heriberto Medina-Franco, Oscar Santes, Jesús Morales-Maza, Alejandro Alfaro-Goldaracena, Martin J. Heslin

Original Article

Efficacy of bi-monthly hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma in patients with decompensated cirrhosis
Kei Moriya, Tadashi Namisaki, Shinya Sato, Masanori Furukawa, Akitoshi Douhara, Hideto Kawaratani, Kosuke Kaji, Mitsuteru Kitade, Naotaka Shimozato, Yasuhiko Sawada, Kenichiro Seki, Soichiro Saikawa, Hiroaki Takaya, Kou Kitagawa, Takemi Akahane, Akira Mitoro, Yasushi Okura, Junichi Yamao, Hitoshi Yoshiji
Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma
Moh’d Khushman, Girijesh Kumar Patel, Javier Ariel Laurini, Arun Bhardwaj, Kelly Roveda, Robert Donnell, Kelley Sherling, Brittany Case, Arthur E. Frankel, Sachin Pai, William Taylor, Marcus Chuan Beng Tan, Meir Mizrahi, Cindy Nelson, Mary Wyatt, Mary Patton, Steven McClellan, Seema Singh, Bin Wang, Ajay P. Singh
Treatment and survival rates of stage IV pancreatic cancer at VA hospitals: a nation-wide study
Ibrahim Azar, Gurjiwan Virk, Saghi Esfandiarifard, Ali Wazir, Syed Mehdi
Molecular profiling of biliary cancers reveals distinct molecular alterations and potential therapeutic targets
Benjamin A. Weinberg, Joanne Xiu, Michael R. Lindberg, Anthony F. Shields, Jimmy J. Hwang, Kelsey Poorman, Mohamed E. Salem, Michael J. Pishvaian, Randall F. Holcombe, John L. Marshall, Michael A. Morse
Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature
Erin J. Song, Corbin D. Jacobs, Manisha Palta, Christopher G. Willett, Yuan Wu, Brian G. Czito
Estimation of hepatocellular carcinoma mortality using aspartate aminotransferase to platelet ratio index
Kelvin Allenson, David Roife, Lillian S. Kao, Tien C. Ko, Curtis J. Wray
Circulating TGF-β1 as the potential epithelial mesenchymal transition-biomarker for diagnosis of cholangiocarcinoma
Phongsaran Kimawaha, Apinya Jusakul, Prem Junsawang, Watcharin Loilome, Narong Khuntikeo, Anchalee Techasen
Predictors of outcomes in patients with gastric cancer treated with contemporary multimodality strategies—a single institution experience
Tuyen Hoang, Michelle Park, Darryl Hiyama, Farshid Dayyani
Assessment of the external validity of the AJCC 8th staging system for small intestinal adenocarcinoma: a time to reconsider the role of tumor location?
Hani Oweira, Omar Abdel-Rahman, Arianeb Mehrabi, Christoph Reissfelder
Interleukin-6 as a biomarker in patients with hepatobiliary cancers
Rohit Gosain, Sidra Anwar, Austin Miller, Renuka Iyer, Sarbajit Mukherjee
Percutaneous radiofrequency versus microwave ablation for management of hepatocellular carcinoma: A randomized controlled trial
Ahmed Kamal, Amr Aly Abd Elmoety, Yousri Abdel Meguid Rostom, Mohamed Said Shater, Sameh Aldesoky Lashen
The roles of p53 and XPO1 on colorectal cancer progression in Yemeni patients
Mohammed Aladhraei, Eman Al-Salami, Naravat Poungvarin, Prasit Suwannalert
Prediction of colorectal cancer risk among adults in a lower middle-income country
Yasara Manori Samarakoon, Nalika Sepali Gunawardena, Aloka Pathirana, Manuja N. Perera, Sumudu Avanthi Hewage
Hematologic markers of distant metastases in gastric cancer
Osama Abu-Shawer, Mohammad Abu-Shawer, Ayman Haimour, Abdullah Alhouri, Ala’a Aldeen Alkhatib, Musaab Abki, Omar Alqaisi, Omar Hamdan, Rahaf Alsaqri, Saeed Ismail, Tamer Altamimi, Maysa Al-Hussaini
Dose escalated concurrent chemo-radiation in borderline resectable and locally advanced pancreatic cancers with tomotherapy based intensity modulated radiotherapy: a phase II study
Shirley Lewis, Supriya Chopra Sastri, Supreeta Arya, Shaesta Mehta, Prachi Patil, Shyamkishore Shrivastava, Reena Phurailatpam, Shailesh Shrikhande, Reena Engineer
Evaluation of pharmacological therapies used in Costa Rica in patients with metastatic gastric cancer: a retrospective study
Eugenia Cordero-García, Allan Ramos-Esquivel, Warner Alpízar-Alpízar
The efficacy of everolimus and sunitinib in patients with sporadic or germline mutated metastatic pancreatic neuroendocrine tumors
Jose Eduardo Nuñez, Mauro Donadio, Duilio Rocha Filho, Juliana Florinda Rego, Milton Barros, Maria Nirvana Formiga, Rossana Lopez, Rachel Riechelmann
Adjuvant radiotherapy in oesophageal cancer with positive circumferential resection margins—recurrence and survival outcomes
Bhamini Vadhwana, Dimitrios Zosimas, Panagis M. Lykoudis, Huan Ming Phen, Maria Martinou, Thangadorai Amalesh, David Khoo
Combined conventional transarterial chemoembolization with Mitomycin and percutaneous ablation for unresectable hepatocellular carcinoma
Ricardo Yamada, Beatriz Bassaco, Stephen Bracewell, Samuel Volin, Heather Collins, Christopher Hannegan, Marcelo Guimarares
The role of sequential radiation following adjuvant chemotherapy in resected pancreatic cancer
Ashwin Shinde, Vivek Verma, Richard Li, Scott Glaser, Mustafa Raoof, Susanne G. Warner, Vincent Chung, Gagandeep Singh, Yi-Jen Chen, Karyn A. Goodman, Arya Amini
The downstaging approach to irresectable oesophageal and gastric cancer: a single centre experience
Nicholas A. Bradley, Christina Wilson, Janet Graham, Jeff Evans, Grant Fullarton, Colin K. Mackay, Carol Craig, David McIntosh, Andrew MacDonald, Derek Grose, Matthew Forshaw
Centers with more therapeutic modalities are associated with improved outcomes for patients with hepatocellular carcinoma
Julie M. Jiang, Nitin Ohri, Justin Tang, Renee Moadel, Jacob Cynamon, Andreas Kaubisch, Milan Kinkhabwala, Madhur K. Garg, Chandan Guha, Rafi Kabarriti
Clinicopathological features and outcomes of fibrolamellar hepatocellular carcinoma
Sakti Chakrabarti, Sri Harsha Tella, Anuhya Kommalapati, Brandon M. Huffman, Siddhartha Yadav, Irbaz Bin Riaz, Gaurav Goyal, Kabir Mody, Mitesh Borad, Sean Cleary, Rory L. Smoot, Amit Mahipal
Adaptive radiation therapy for cervical esophageal cancer: dosimetric and volumetric analysis
Sibel Karaca, Meltem Kırlı
Vertebral body irradiation during chemoradiation therapy for esophageal cancer contributes to acute bone marrow toxicity
Andrew Zhang, Matthew P. Deek, Sinae Kim, Mutlay Sayan, Alison Grann, Raquel T. Wagman, Usha Malhotra, Lara Hathout, Nrusingh Biswal, Yin Zhang, John Langenfeld, Timothy Kennedy, David A. August, Salma K. Jabbour
Patterns of care and outcomes of intensity modulated radiation therapy versus three-dimensional conformal radiation therapy for anal cancer
Anna Lee, Ashley Albert, Niki Sheth, Paul Adedoyin, Jared Rowley, David Schreiber
Yield of endoscopy of the lower digestive tract in relation to ethnic descent
Ruud J. L. F. Loffeld, Boris Liberov, Pascale E. P. Dekkers
The impact of the open-access status on journal indices: oncology journals
Saif Aldeen AlRyalat, Anas Abu Nassar, Faris Tamimi, Esraa Al-Fraihat, Lama Assaf, Razan Ghareeb, Mahmoud Masoudi, Mohammad Al-Essa
Phase II trial of levocetirizine with capecitabine and bevacizumab to overcome the resistance of antiangiogenic therapies in refractory metastatic colorectal cancer
Manik Amin, Monica Desai, Kathryn Trinkaus, Amberly Brown, Andrea Wang-Gillam, Benjamin Tan, Joel Picus, Steven Sorscher, Maureen Highkin, Kim Lears, Albert C. Lockhart
Survival benefits and predictors of use of chemoradiation compared with radiation alone for early stage (T1-T2N0) anal squamous cell carcinoma
Irini Youssef, Virginia Osborn, Anna Lee, Evangelia Katsoulakis, Ami Kavi, Kwang Choi, Joseph Safdieh, David Schreiber
Comparison of definitive chemoradiation with 5-fluorouracil versus capecitabine in anal cancer
Yoanna Pumpalova, Margaret M. Kozak, Rie von Eyben, Pamela Kunz, George Fisher, Daniel T. Chang, Sigurdis Haraldsdottir
Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation
Abhilasha Patel, Gyanendra Tripathi, Philip McTernan, Kishore Gopalakrishnan, Omar Ali, Emma Spector, Nigel Williams, Ramesh P. Arasaradnam
Feasibility of circulating tumor DNA testing in hepatocellular carcinoma
Kabir Mody, Pashtoon Murtaza Kasi, Ju Dong Yang, Phani Keerthi Surapaneni, Ashton Ritter, Ali Roberts, Rebecca Nagy, Mitesh J. Borad
Disparities in colon and rectal cancer queried individually between Hispanics and whites
Jenna Koblinski, Jana Jandova, Viraj Pandit, Pamela Omesiete, Valentine Nfonsam
Timing of surgery following neoadjuvant chemoradiation in rectal cancer: a retrospective analysis from an academic medical center
Seth Maliske, Justin Chau, Timothy Ginader, John Byrn, Sudershan Bhatia, Andrew Bellizzi, Daniel J. Berg, Varun Monga
Gender differences in health-related quality of life among patients with colorectal cancer
Delara Laghousi, Esmat Jafari, Hosseinali Nikbakht, Behnam Nasiri, Morteza Shamshirgaran, Nayyereh Aminisani
Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management
Fábio Guilherme Campos, Carlos Augusto Real Martinez, Marianny Sulbaran, Leonardo Alfonso Bustamante-Lopez, Adriana Vaz Safatle-Ribeiro
A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study
Hala M. Hatab, Fatma F. Abdel Hamid, Ahmed F. Soliman, Tamer A. Al-Shafie, Yahia M. Ismail, Motawa E. El-Houseini
Neoadjuvant therapy and pancreatic cancer: a national cancer database analysis
Ravi Shridhar, Caitlin Takahashi, Jamie Huston, Kenneth L. Meredith
Endoscopic and clinicopathological characteristics of gastrointestinal adult T-cell leukemia/lymphoma
Hideki Ishibashi, Satoshi Nimura, Yoshiyuki Kayashima, Yasushi Takamatsu, Hiroki Iwasaki, Naohiko Harada, Seiya Momosaki, Hidenori Takedatsu, Shotaro Sakisaka, Morishige Takeshita
Analyzing the impact of neoadjuvant radiation dose on pathologic response and survival outcomes in esophageal and gastroesophageal cancers
Richard Li, Ashwin Shinde, Scott Glaser, Joseph Chao, Jae Kim, Sana D. Karam, Karyn Goodman, Yi-Jen Chen, Arya Amini
Safety and efficacy of locoregional therapy for metastatic pancreatic ductal adenocarcinoma to the liver: a single-center experience
Ryan Earl Bailey, Phani Keerthi Surapaneni, Jacob Core, Lucas Lauar Cortizo Vidal, Jordan LeGout, Charles Ritchie, Gregory Frey, J. Mark McKinney, David Sella, Ricardo Paz-Fumagalli, Beau Toskich, Kabir Mody
Medical record review of transition to lanreotide following octreotide for neuroendocrine tumors
Muhammad Wasif Saif, Rohan Parikh, David Ray, James A. Kaye, Samantha K. Kurosky, Katharine Thomas, Robert A. Ramirez, Thorvardur R. Halfdanarson, Thomas J. R. Beveridge, Beloo Mirakhur, Saurabh P. Nagar, Heloisa P. Soares
Pre-operative percutaneous endoscopic gastrostomy tube placement does not increase post-operative complications or mortality in oesophageal cancer
M. Zeeshan Siddique, Shafqat Mehmood, M. Ismail, Ammara Yasmeen, Asad-Ur- Rehman, Muhammad Abu Bakar, Shahid Khattak, Aamir Ali Syed, M. Aasim Yusuf

Review Article

The assessment of intraoperative technique-related risk factors and management of anastomotic leakage after esophagectomy: a systematic review
Chuangui Chen, Hongjing Jiang, Zhentao Yu
Radiation therapy for rectal cancer
Michelle Tseng, Yu Yang Soon, Balamurugan Vellayappan, Francis Ho, Jeremy Tey
Transanal total mesorectal excision for rectal cancer: hype or new hope?
Chien-Chih Chen, Yi-Ling Lai, Andy Yi-Ming Cheng, Chun-Ho Chu, I-Ping Huang, Shung-Haur Yang
Pelvic exenteration for locally advanced and recurrent rectal cancer—how much more?
Yee Chen Lau, Kilian G. M. Brown, Peter Lee
Diagnostic and management strategies for lateral pelvic lymph nodes in low rectal cancer—a review of the evidence
Dedrick Kok Hong Chan, Ker-Kan Tan, Takashi Akiyoshi
Status of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from colorectal cancer
Seung Yoon Yang, Jae Hyun Kang, Ho Seung Kim, Yoon Dae Han, Byung Soh Min, Kang Young Lee
MicroRNA-122 in patients with hepatitis B and hepatitis B virusassociated hepatocellular carcinoma
Mohammad Reza Mahmoudian-Sani, Samira Asgharzade, Arash Alghasi, Ali Saeedi-Boroujeni, Seyed Jafar Adnani Sadati, Mohammad Taghi Moradi
Endoscopic stenting in colorectal cancer
Tian-Zhi Lim, Ker-Kan Tan
Cardiovascular complications of metastatic colorectal cancer treatment
Kalliopi Keramida, Georgios Charalampopoulos, Dimitrios Filippiadis, Elias Tsougos, Dimitrios Farmakis
Proton beam radiotherapy for pancreas cancer
Michael S. Rutenberg, Romaine C. Nichols
Robotic surgery in colorectal cancer: the way forward or a passing fad
James Chi-Yong Ngu, Seon-Hahn Kim
Proton beam therapy for liver cancers
Michael Chuong, Adeel Kaiser, Jason Molitoris, Alejandra Mendez Romero, Smith Apisarnthanarax

Case Report

Report of three cases of gastric choriocarcinomas—an emphasis on morphologic changes in the non-affected gastric mucosa
Janet C. Guzmán-López, Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández, César Zepeda-Najar
Concomitant KRAS and BRAF mutations in colorectal cancer
Lauren Midthun, Shagufta Shaheen, Jeremy Deisch, Maheswari Senthil, James Tsai, Chung-Tsen Hsueh
Hyperammonemic encephalopathy in a patient with fibrolamellar hepatocellular carcinoma: case report and literature review
Janice Cho, Joy C. Y. Chen, Jonas Paludo, Erin E. Conboy, Brendan C. Lanpher, Steven R. Alberts, Thorvardur R. Halfdanarson
Mucinous adenocarcinoma arising from chronic perianal fistula—a multidisciplinary approach
Tamara Díaz-Vico, Daniel Fernández-Martínez, Carmen García-Gutiérrez, Aida Suárez-Sánchez, Isabel Cifrián-Canales, Guillermo Eduardo Mendoza-Pacas, Herminio Sánchez-Farpón, Nuria Truán-Alonso
Primary squamous cell carcinoma of the peristomal skin of gastrostomy in a transplant patient: a first case report
Aurore Lailheugue, Jean-Baptiste Gibier, Guillaume Lassailly, Stéphanie Truant, François-René Pruvot, Mehdi El Amrani
Personalised approach in combined treatment of cholangiocarcinoma: a case report of healing from cholangiocellular carcinoma at stage IV
Timur Bunyatov, Alexey Zhao, Juriy Kovalenko, Beslan Gurmikov, Vladimir Vishnevsky

Letter to the Editor

Is postoperative ambulation a component or a marker of enhanced recovery after surgery?
Karem Slim
Direct oral anticoagulants in gastrointestinal malignancies: is the convenience worth the risk?
Namisha Thapa, Joseph Shatzel, Thomas G. Deloughery, Sven R. Olson

Short Communication

Stop hedging your bets: reasons for non-adherence to a tri-modality regimen in the treatment of esophageal cancer in a multidisciplinary setting
Ramtin Rahmani, Daniel Koffler, Kelly R. Haisley, John G. Hunter, Claude Poliakoff, Charles R. Thomas Jr, John M. Holland, James P. Dolan, Nima Nabavizadeh
Optimal radiation dosing in concurrent neoadjuvant chemoradiation for resectable esophageal cancer: a meta-analysis
Steven Engel, Adam Awerbuch, Deukwoo Kwon, Omar Picado, Raphael Yechieli, Danny Yakoub, Lorraine Portelance

Special Report

Feasibility and clinical value of circulating tumor DNA testing in patients with gastric adenocarcinomas
Madiha Iqbal, Ali Roberts, Jason Starr, Kabir Mody, Pashtoon Murtaza Kasi

Study Protocol

Evaluation of confocal endoscopic microscopy for detection of early-stage gastric cancer in hereditary diffuse gastric cancer (HDGC) syndrome
Samantha Ruff, Bryan Curtin, Martha Quezado, Theo Heller, Christopher Koh, Seth M. Steinberg, Maureen Connolly, Jonathan M. Hernandez, Jeremy L. Davis