Article Abstract

Adaptive radiation therapy for cervical esophageal cancer: dosimetric and volumetric analysis

Authors: Sibel Karaca, Meltem Kırlı


Background: Cervical esophageal cancer (CEC) patients may suffer from significant anatomical changes due to tumor shrinkage or weight loss during radiotherapy. The aim of the study is to evaluate the volumetric and dosimetric changes in the target and critical volumes of CEC patients by using adaptive radiotherapy (ART) technique.
Methods: Seven CEC patients treated in helical tomotherapy (HT) unit was analyzed. All patients had a replanning CT simulation at 3rd (CT2) and 5th (CT3) weeks in addition to the initial CT (CT1). Volumetric and dosimetric changes of target and organs at risk (OAR) were evaluated.
Results: The average weight loss of the patients was 9.03%. The major changes of the planning target volume (PTV), PTV boost, right and left parotid volumes were 4.74%; 15.93%; 26.82% and 26.64%, respectively. Using ART software was evaluated with first planning values (CT1) and pre-CT2-CT3 verification values. The correlation was decrease of the D95 and increase of the Dmax was statistically significant. When evaluated the varying values of the new CTs, there was no significant change between the initial PTV and adapted PTV’s. But a significant decrease was observed at the summation plan for left and right parotids (P<0.05). The mean dose reductions of left and right parotid were 2.48 and 2.49 Gy, respectively.
Conclusions: Our results showed that using ART technique was beneficial to ensure adequate doses to the target volumes and safe doses to the OARs for the patients who need replanning during RT in uncommon CEC patients.

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